Zypadhera ® (olanzapin)

För fullständig produktresumé för Zypadhera® se FASS.

Denna information är endast avsedd för sjukvårdspersonal verksam i Sverige och som svar på din fråga. Informationen nedan är på engelska

ZypAdhera® (olanzapinpamoat): Tid till full effekt

Olanzapinpamoat ger terapeutiska nivåer av systemisk olanzapin från den första injektionen. Men det krävs cirka 3 månader för att återupprätta steady state.

Label information

Patients should be monitored carefully for signs of relapse during the first one to two months of treatment.1

During antipsychotic treatment, improvement in the patient's clinical condition may take several days to some weeks. Patients should be closely monitored during this period.1

Pharmacokinetic considerations

During the initial three months of treatment with olanzapine pamoate, accumulation of olanzapine was observed but there was no additional accumulation during long-term use (12 months) in patients who were injected with up to 300 mg every two weeks.1

To compensate for the slightly lower systemic olanzapine concentrations during this initial treatment period, use of a loading dose for at least the first 2 months of treatment is recommended.2 For further information on loading dose please refer to the dosing as described in the summary of product characteristics section 4.2

After a single intramuscular injection with olanzapine pamoate, the slow dissolution of the olanzapine pamoate salt in muscle tissue begins immediately and provides a slow continuous release of olanzapine for more than four weeks.1

The half-life of olanzapine after olanzapine pamoate is 30 days compared to 30 hours following oral administration.1


1. ZypAdhera [summary of product characteristics] Eli Lilly Netherland B.V., The Netherlands.

2. Detke HC, Zhao F, Garhyan P, Carlson J, McDonnell D. Dose correspondence between olanzapine long-acting injection and oral olanzapine: recommendations for switching. Int Clin Psychopharmacol. 2011;26(1):35-42. http://dx.doi.org/10.1097/YIC.0b013e32834093d1

Datum fӧr senaste ӧversyn May 01, 2019

Kontakta Medicinsk Information på Lilly

Kontakta oss på telefon

Kontorstid vardagar 9.00-17.00

Eller så kan du

Klicka för att chatta är tillgänglig

Klicka för att chatta är offline

Skriv din fråga till oss