Trulicity ® (dulaglutid) injektion

För fullständig produktresumé för Trulicity® se FASS.

Denna information är endast avsedd för sjukvårdspersonal verksam i Sverige och som svar på din fråga. Informationen nedan är på engelska

Trulicity® (dulaglutid): Glömd dos

Dulaglutide försenar magtömning och försiktighet bör iakttas när dulaglutid administreras samtidigt med orala läkemedel.

Detailed Information

If a dose is missed, it should be administered as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose.1

If less than 3 days (72 hours) remain before the next scheduled dose, the missed dose should be skipped and the next dose should be administered on the regularly scheduled day.1

In each case, patients can then resume their regular once weekly dosing schedule.1

The day of weekly administration can be changed if necessary, as long as the last dose was administered 3 or more days (72 hours) before.1

Pharmacokinetics

Improvement in glycemic control can be observed after the first dulaglutide dose and is sustained throughout the once-weekly dosing interval.1,2

Steady-state plasma concentrations are achieved between 2 and 4 weeks following once-weekly administration.1,3

Once steady state is achieved, missing 2 or more consecutive doses may result in subtherapeutic dulaglutide concentrations (Figure 1).3

Figure 1. Effect of Missed 1.5 mg Once-Weekly Doses on Dulaglutide Pharmacokinetics at Steady State3

References

1. Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

2. Geiser JS, Heathman MA, Cui X, et al. Clinical pharmacokinetics of dulaglutide in patients with type 2 diabetes: analyses of data from clinical trials. Clin Pharmacokinet. 2016;55(5):625-634. http://rd.springer.com/article/10.1007%2Fs40262-015-0338-3

3. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Datum fӧr senaste ӧversyn 2020 M01 06


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