Trulicity ® (dulaglutid) injektion

För fullständig produktresumé för Trulicity® se FASS.

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Trulicity® (dulaglutid): Första och andra fasens insulinsekretion

Behandling med dulaglutide ökade både första och andra fasens insulinsekretion jämfört med placebo.

Effect of Dulaglutide on First- and Second- Phase Insulin Secretion

Both first- and second-phase insulin secretion were increased in patients with T2DM treated with dulaglutide compared with placebo.1

A pharmacodynamic study with dulaglutide 1.5 mg in healthy subjects and in patients with T2DM demonstrated a restoration of first-phase insulin secretion.2 

In this 2-period crossover study, subjects received

  • a single subcutaneous dose of dulaglutide 1.5 mg

  • or placebo on day 1 of each period.2

On day 3, subjects underwent a 6-hour insulin infusion, followed by a glucose bolus administered intravenously.2

The first-phase insulin response in patients with T2DM on dulaglutide 1.5 mg treatment exceeded the response observed in healthy subjects on placebo.2

Dulaglutide 1.5 mg treatment also improved second-phase insulin secretion in response to a single intravenous bolus of glucose in both healthy subjects and in T2DM patients (Figure 1).2

Figure 1. Mean Plasma Insulin Concentrations vs Time for Healthy Subjects and Patients With T2DM Following Dulaglutide 1.5 mg Treatment on Day 1 and a Glucose Bolus (50% Dextrose) Administered After a 6-hour Insulin Infusion on Day 32

Abbreviations: IV = intravenous; T2DM = type 2 diabetes mellitus.

References

1. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

2. de la Peña A, Loghin C, Cui X, et al. Once-weekly dulaglutide 1.5 mg restores insulin secretion in response to intravenous glucose infusion. Diabetes Obes Metab. 2017;19(4):517-523. http://dx.doi.org/10.1111/dom.12847

Glossary

T2DM = Type 2 Diabetes Mellitus

Datum fӧr senaste ӧversyn 2020 M04 06


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