Om du vill rapportera en biverkning gällande en av Lillys produkter, kontakta oss via e-post på DK_PHv@lilly.com eller på telefon 08-737 88 00. Har du ytterligare medicinska frågor gällande en av Lillys produkter, kontakta oss via länken ovan.
Retsevmo ® (selperkatinib)
Denna information är endast avsedd för sjukvårdspersonal verksam i Sverige och som svar på din fråga. Informationen nedan är på engelska
The RET RTK has critical roles in normal kidney and enteric nervous system development and in the maintenance of several adult tissue types, including
male germ cell tissues.1
The RET RTK is the receptor for ligands belonging to the GFL. The GFL are composed of GDNF, neurturin, persephin, and artemin. These ligands are not able to bind RET on their own, but require a ligand-binding subunit acting as a co-receptor, known as GFRα co-receptors. During RET activation, the GFL bind to 4 different GFRα co-receptors.1
The GFL–GFRα complex induces RET homodimerization, which activates intracellular kinase domains. This action results in RET receptor autophosphorylation and subsequent downstream activation of signal transduction pathways responsible for
RET can be altered by 2 primary mechanisms
chromosomal rearrangements that fuse the RET kinase domain with a partner protein dimerization domain producing hybrid proteins with ligand-independent activity,2-5 or
point mutations that directly or indirectly activate the RET kinase.6-8
Genetic alterations in the RET gene are implicated in the pathogenesis of several human cancers. For RET, fusions and mutations are the key alterations.7 The term RET-altered cancers encompasses RET-fusions and RET-mutations, as described in Table 1.
abnormalities that occur when the RET gene becomes fused
with another unrelated gene.
Genomic abnormalities that occur when a small change in the RET gene alters the function of the protein, causing uncontrolled cell growth.
Most common alterations
KIF5B in lung cancer
CCDC6 and NCOA4 in thyroid cancer
2% of NSCLC
10-20% of papillary and other thyroid cancers
1% of pancreatic cancer, salivary gland cancer, Spitz cancer, CRC, ovarian cancer, myeloproliferative disorder
Appears to be limited to MTC, with approximately
>60% in sporadic MTC, and
>90% in hereditary MTC.
Abbreviations: CCDC6 = coiled-coil domain containing 6; CRC = colorectal cancer; KIF5B = kinesin family member 5B; MTC = medullary thyroid cancer; NCOA4 = nuclear receptor coactivator 4; NSCLC = non-small cell lung cancer; RET = rearranged during transfection.
Figure 1. A detailed visual representation of the mechanism of disease of RET-altered cancers may be accessed by clicking here.
1. Drilon A, Hu ZI, Lai GG, et al. Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes. Nat Rev Clin Oncol. 2018;15(3):151-167. https://doi.org/10.1038/nrclinonc.2017.175
2. Romei C, Ciampi R, Elisei, R. A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma. Nat Rev Endocrinol. 2016;12(4):192-202. https://doi.org/10.1038/nrendo.2016.11
3. Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012;18(3):375-377. https://doi.org/10.1038/nm.2644
4. Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18(3):378-381. https://doi.org/10.1038/nm.2658
5. Lipson D, Capelletti M, Yelensky R, et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med. 2012;18(3):382-384. https://doi.org/10.1038/nm.2673
6. Donis-Keller H, Dou S, Chi D, et al. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet. 1993;2(7):851-856. https://doi.org/10.1093/hmg/2.7.851
7. Mulligan LM, Kwok JB, Healey CS, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature. 1993;363(6428):458-460. http://dx.doi.org/10.1038/363458a0
8. Hofstra RM, Landsvater I, Ceccherini I, et al. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature. 1994;367(6461):375-376. https://doi.org/10.1038/367375a0
9. Pietrantonio F, Di Nicolantonio F, Schrock AB, et al. RET fusions in a small subset of advanced colorectal cancers at risk of being neglected. Ann Oncol. 2018;29(6):1394-1401. https://dx.doi.org/10.1093/annonc/mdy090
10. Su X, He C, Ma J, et al. RET/PTC rearrangements are associated with elevated postoperative TSH levels and multifocal lesions in papillary thyroid cancer without concomitant thyroid benign disease. PLoS One. 2016;11(11):e0165596. https://dx.doi.org/10.1371/journal.pone.0165596
GDNF = glial cell derived neurotrophic factor
GFL = glial cell derived neurotrophic factor family ligands
GFRα = glial cell derived neurotrophic factor family receptor alpha
RET = rearranged during transfection
RTK = receptor tyrosine kinase
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.
Datum fӧr senaste ӧversyn 2021 M01 22