Baqsimi ® (glukagon näspulver)

För fullständig produktresumé för Baqsimi® se FASS.

Denna information är endast avsedd för sjukvårdspersonal verksam i Sverige och som svar på din fråga. Informationen nedan är på engelska

Kan Baqsimi® (Glukagon näspulver) användas hos patienter med lungsjukdomar?

Eli Lilly and Company har inte studerat användningen av nasal glukagon hos patienter med diabetes och olika lungsjukdomar.

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Detailed Information

Nasal glucagon (NG) is absorbed in the nasal cavity.

In the NG adult pivotal study, five participants reported asthma at baseline. One participant withdrew from the study before completing both dosing visits.1

In the NG pediatric pivotal study, five participants reported asthma at baseline, and they all completed the study.1

The efficacy and safety of the use of NG in diabetic people with the following lung diseases are unknown:

  • chronic obstructive pulmonary disease
  • emphysema
  • chronic bronchitis
  • cystic fibrosis
  • bronchietasis
  • pneumonia
  • pleural effusion
  • interstitial lung disease
  • lung cancer
  • pulmonary hypertension
  • pulmonary fibrosis 
  • sarcoidosis, or
  • requiring oxygen.

Preclinical Toxicology Animal Studies

Rats were administered a single dose of 0.5 mg NG by intra-tracheal administration, and it was well tolerated.1,2

The direct introduction of NG into the rats’ lungs did not produce abnormal gross pathology or histopathological findings.1,2 Therefore, the authors suggest that inadvertent lung exposure to NG is likely to be well tolerated.2 

References

1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

2Reno FE, Normand P, McInally K, et al. A novel nasal powder formulation of glucagon: toxicology studies in animal models. BMC Pharmacol Toxicol. 2015;16(1):29. https://doi.org/10.1186/s40360-015-0026-9

Datum fӧr senaste ӧversyn 2019 M08 23


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