Om du vill rapportera en biverkning gällande en av Lillys produkter, kontakta oss via e-post på DK_PHv@lilly.com eller på telefon +45 4526 6040. Har du ytterligare medicinska frågor gällande en av Lillys produkter, kontakta oss via länken ovan.
Emgality ® (galkanezumab)
Denna information är endast avsedd för sjukvårdspersonal verksam i Sverige och som svar på din fråga. Informationen nedan är på engelska
Potential Drug-Drug Interactions With Anticoagulants or Other Drugs/Substances Involved With Clotting
Pharmacokinetic Characteristics
As a humanised IgG4 monoclonal antibody, galcanezumab is expected to be degraded into small peptides and amino acids via catabolic pathways in the same manner as endogenous IgG.1,2
As such, it is not expected to
inhibit metabolic or induce enzymatic pathways
be metabolized by the cytochrome P450 families of drug-metabolizing enzymes, and
produce any active metabolites.2-4
Drug Interactions Studies Were Not Conducted
No drug interaction studies were conducted. No pharmacokinetic drug interactions are expected based on the characteristics of galcanezumab.1
There are no known interactions for galcanezumab, drug-drug or otherwise.3
1. Emgality [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
2. Kielbasa W, Helton DL. A new era for migraine: Pharmacokinetic and pharmacodynamic insights into monoclonal antibodies with a focus on galcanezumab, an anti-CGRP antibody. Cephalalgia. 2019;39(10):1284-1297. http://dx.doi.org/10.1177/0333102419840780
3. Data on file, Eli Lilly and Company and/or one of its subsidiaries.
4. Lobo ED, Hansen RJ, Balthasar JP. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci. 2004;93(11):2645-2668. https://doi.org/10.1002/jps.20178
Glossary
CGRP = calcitonin gene-related peptide
IgG = immunoglobulin G
IgG4 = immunoglobulin G (subclass) 4
PK = pharmacokinetics
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.
Datum fӧr senaste ӧversyn 2020 M04 09