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Baqsimi ® (glukagon näspulver)
Denna information är endast avsedd för sjukvårdspersonal verksam i Sverige och som svar på din fråga. Informationen nedan är på engelska
Alcohol-induced hypoglycemia is mediated by multiple factors including
inhibition of gluconeogenesis, and
initial maintenance of liver glucose production by glycogenolysis until glycogen stores are depleted.1
As such, a person with alcohol-induced hypoglycemia may not have adequate hepatic stores of glycogen present, which may impact the effectiveness of glucagon.
Glucagon Mechanism of Action and Glycogen
Glucagon increases BG concentration by activating hepatic glucagon receptors, thereby stimulating
hepatic glycogen breakdown, and
the release of glucose from the liver.2
Hepatic stores of glycogen are necessary for glucagon to produce an antihypoglycemic effect.2
NG is effective in treating hypoglycemia only if sufficient hepatic glycogen is present.2
Because glucagon is of little or no help in states of starvation, adrenal insufficiency, or chronic hypoglycemia, patients with these conditions should be treated with glucose.2
Use of Glucagon Nasal Powder
NG is indicated for the treatment of severe hypoglycaemia in adults, adolescents, and children aged 4 years and over with diabetes mellitus.2
After giving the dose, the caregiver should call for medical help right away.2
1. Tetzschner R, Norgaard K, Ranjan A. Effects of alcohol on plasma glucose and prevention of alcohol-induced hypoglycemia in type 1 diabetes - a systemic review with GRADE. Diabetes Metab Res Rev. 2018;34:e2965. http://doi.org/10.1002/dmrr.2965
2. Baqsimi [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
Glossary
BG = blood glucose
NG = nasal glucagon (glucagon nasal powder)
Datum fӧr senaste ӧversyn 2019 M08 19