Abasaglar® (insulin glargin): Uppnående av HbA1c Mindre än 7%

Clinical Studies - Type 1 and Type 2 Diabetes Mellitus

Adult patients with inadequately controlled T1DM participated in a 24-week, open-label, active-controlled study with a 28-week extension to evaluate the glucose lowering effect of once-daily Abasaglar compared with that of once-daily administration of Lantus, both in combination with mealtime insulin lispro.¹

Adult patients with T2DM participated in a double-blind, active-controlled study to evaluate the glucose lowering effect of once-daily Abasaglar plus OAMs compared with that of Lantus administered once daily along with OAMs. Patients were

• insulin naïve (~60%) and had failed to achieve adequate glycemic control on at least 2 OAMs, or

• already on Lantus along with at least 2 OAMs with adequate or inadequate glycemic control (~40%).²

Results

At week 24, the percentage of patients who achieved HbA1c levels less than 7% was similar between treatment groups (Table 1).^1,2

Table 1. Achievement of HbA1c Levels Less Than 7% at 24 Weeks in Phase 3 Clinical Studies of Abasaglar^1,2

Abbreviations: Abasaglar = Abasaglar® (insulin glargine) 100 units/mL; HbA1c = glycated hemoglobin; Lantus = Lantus® (insulin glargine) 100 units/mL; LOCF = last observation carried forward; OAM = oral antihyperglycemic medication; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus.

^a Data from LOCF; p>.05 for all within-study treatment comparisons.

References

1. Blevins TC, Dahl D, Rosenstock J, et al. Efficacy and safety of LY2963016 insulin glargine compared with insulin glargine (Lantus®) in patients with type 1 diabetes in a randomized controlled trial: the ELEMENT 1 study. Diabetes Obes Metab. 2015;17(8):726-733. http://dx.doi.org/10.1111/dom.12496

2. Rosenstock J, Hollander P, Bhargava A, et al. Similar efficacy and safety of LY2963016 insulin glargine and insulin glargine (Lantus®) in patients with type 2 diabetes who were insulin-naïve or previously treated with insulin glargine: a randomized, double-blind controlled trial (the ELEMENT 2 study). Diabetes Obes Metab. 2015;17(8):734-741. http://dx.doi.org/10.1111/dom.12482

Glossary

Abasaglar = Abasaglar® (insulin glargine) 100 units/mL

HbA1c = glycated hemoglobin

Lantus = Lantus® (insulin glargine) 100 units/mL

OAM = oral antihyperglycemic medication

T1DM = type 1 diabetes mellitus

T2DM = type 2 diabetes mellitus