Zyprexa ® (olanzapine)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

Zyprexa® (olanzapine): Feeding tube

Administration of Zyprexa coated tablets or Zyprexa Velotab through a feeding tube is not part of the approved methods of administration. Lilly has no data to support the administration of Zyprexa through a gastric tube.


Handling and Safety Concerns

Exposure to tablet powder (either airborne or by dermal contact) generated during the breaking or crushing of olanzapine tablets has the potential risks for contact dermatitis following repeated exposure.1

Symptoms have included rash with redness, swelling, and scaling of the affected skin areas. Positive reactions have been verified by patch testing with olanzapine (0.1%). Based on the clinical dose, olanzapine is highly potent.1

Likewise, olanzapine may be irritating to the eyes based on animal studies. Attention and care should be exercised not to inadvertently transfer material from the hands to the eye.2

Additional safety information about olanzapine can be found in the full prescribing information and the Material and Safety Data Sheet, available upon request from Eli Lilly and Company.


1Olanzapine [material safety data sheet]. Indianapolis, IN: Eli Lilly and Company; 2019.

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 08 January 2021

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