Zyprexa ® (olanzapine)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

Zyprexa® (olanzapine): Breaking or Dividing Tablets

Zyprexa coated tablets are not scored and not intended to be broken or divided. The package leaflet recommends swallowing the tablets whole with water.


Additional Safety Information

Confirmed cases of allergic contact dermatitis have been reported with olanzapine. Symptoms have included rash with redness, swelling, and scaling of the affected skin areas. Positive reactions have been verified by patch testing with olanzapine (0.1%). Based on the clinical dose, olanzapine is highly potent.1

Likewise, olanzapine may be irritating to the eyes based on animal studies. Care should be exercised not to inadvertently transfer material from the hands to the eye.2

Additional safety information about olanzapine can be found in the full prescribing information and in the material safety data sheet for olanzapine, available upon request from Eli Lilly and Company.


1Olanzapine [materials safety data sheet]. Eli Lilly and Company: Indianapolis, IN, August 11, 2015. http://ehs.lilly.com/msds/Zyprexa%20(tablets).pdf . Accessed October 10, 2019.

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 10 October 2019

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