ZypAdhera ® (olanzapine pamoate monohydrate)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: ZypAdhera Summary of Product Characteristics (SmPC)

ZypAdhera® (olanzapine pamoate): Switching from High Oral Olanzapine Dose

First olanzapine pamoate dose is identified by the target oral olanzapine dose. The highest recommended dose is 300 mg/2 weeks corresponding to 20 mg oral olanzapine per day. Higher olanzapine pamoate doses have not been tested.

Further Label Information

Patients should be treated initially with oral olanzapine before administering olanzapine pamoate, to establish tolerability and response.1

In order to identify the first olanzapine pamoate dose for all patients, the scheme in Table 1 should be considered.1

Table 1. Recommended dose scheme between oral olanzapine and olanzapine pamoate1

Target oral olanzapine dose

Recommended starting dose of olanzapine pamoate

Maintenance dose after 2 month of olanzapine pamoate treatment

10 mg/day

210 mg/2 weeks
or 405 mg/4 weeks

150 mg/2 weeks
or 300 mg/4 weeks

15 mg/day

300 mg/2 weeks

210 mg/2 weeks
or 405 mg/4 weeks

20 mg/day

300 mg/2 weeks

300 mg/2 weeks

Olanzapine LAI doses greater than 405 mg/every 4 weeks or 300 mg/every 2 weeks have not been evaluated in clinical trials.2


1. ZypAdhera [summary of product characteristics] Eli Lilly Netherland B.V., The Netherlands.

2. Data on file, Eli Lilly and Company and/or one of its subsidiaries.


LAI = long-acting injection = olanzapine pamoate

Date of Last Review: May 01, 2019

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