ZypAdhera ® (olanzapine pamoate monohydrate)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: ZypAdhera Summary of Product Characteristics (SmPC)

ZypAdhera® (olanzapine pamoate): Switch Between 2-weeks and 4-weeks Interval

Doses of 150 mg/2 weeks or 300 mg/4 weeks are recommended. Doses of 210 mg/2 weeks or 405 mg/4 weeks are recommended. There is no 4-week dose equivalent for doses of 300 mg/2 weeks.

Approved Dosing

Patients should be treated initially with oral olanzapine before administering olanzapine pamoate, to establish tolerability and response.1

In order to identify the first olanzapine pamoate dose for all patients, the scheme in Table 1 should be considered.1

Table 1. Recommended dose scheme between oral olanzapine and olanzapine pamoate1

Target oral olanzapine dose

Recommended starting dose of olanzapine pamoate

Maintenance dose after 2 month of olanzapine pamoate treatment

10 mg/day

210 mg/2 weeks
or 405 mg/4 weeks

150 mg/2 weeks
or 300 mg/4 weeks

15 mg/day

300 mg/2 weeks

210 mg/2 weeks
or 405 mg/4 weeks

20 mg/day

300 mg/2 weeks

300 mg/2 weeks

During treatment, dose may subsequently be adjusted on the basis of individual clinical status. After clinical reassessment, dose may be adjusted within the range 150 mg to 300 mg every 2 weeks or 300 to 405 mg every 4 weeks (Table 1).1

For full information on dosing please refer to the summary of product characteristics.


1. ZypAdhera [summary of product characteristics] Eli Lilly Netherland B.V., The Netherlands.

Date of Last Review: May 01, 2019

Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at ukmedinfo@lilly.com

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request