ZypAdhera ® (olanzapine pamoate monohydrate)

ZypAdhera® (olanzapine pamoate): Oral Supplementation (label)

Oral olanzapine supplementation is not required, but if clinically necessary, the combined dose from olanzapine pamoate and oral olanzapine should not exceed the corresponding maximum oral olanzapine dose of 20 mg/day.

Information from the Summary of Product Characteristics

Supplementation with oral olanzapine was not authorised in double-blind clinical studies.1

Due to the slow dissolution of the olanzapine pamoate salt, which provides a slow continuous release of olanzapine that is complete approximately six to eight months after the last injection, supervision by a clinician, especially during the first 2 months after discontinuation of olanzapine pamoate, is needed when switching to another antipsychotic product and is considered medically appropriate.1


1. ZypAdhera [summary of product characteristics] Eli Lilly Netherland B.V., The Netherlands.

Date of Last Review: May 01, 2019

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