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ZypAdhera ® (olanzapine pamoate monohydrate)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
ZypAdhera® (olanzapine pamoate): More or all solvent used
There is more diluent in the diluent vial than is needed to complete the reconstitution. If more diluent is added than directed in the instructions for use, the final dose will be less than 150 mg/ml. This can lead to an incorrect dose being administered.
Lilly cannot provide guidance to use the product in a way that is not specified in the label.1
Solvent Volume for Reconstitution
Table 1 provides the amount of solvent required to reconstitute olanzapine pamoate powder for prolonged release suspension for injection.2
Table 1. Determine the amount of solvent required to reconstitute olanzapine pamoate powder for prolonged release suspension for injection.2
|
ZypAdhera vial strength (mg) |
Volume of solvent to add (ml) |
|
210 |
1.3 |
|
300 |
1.8 |
|
405 |
2.3 |
It is important to note that there is more solvent in the vial than is needed to reconstitute.
Each vial of solvent across all strengths contains 3 ml of solvent.2
After reconstitution as directed in the label, each ml of suspension contains 150 mg olanzapine.2
1. Data on file, Eli Lilly and Company and/or one of its subsidiaries.
2. ZypAdhera [summary of product characteristics] Eli Lilly Netherland B.V., The Netherlands.
Date of Last Review: 13 February 2020
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