Verzenios ® ▼ (abemaciclib)

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What was the incidence and management of venous thromboembolic events with Verzenios® ▼ (abemaciclib) in early breast cancer?

Venous thromboembolic events were reported in 2.5% of patients in the abemaciclib arm, compared to 0.6% in the ET alone arm of monarchE, and was managed with dose reductions, dose holds and anticoagulation therapy.


Management recommendations for Venous thromboembolic events (VTEs) in early breast cancer

Dose modification and management recommendations are summarized inDose Modification and Management - VTEs . 

Dose Modification and Management - VTEs1


Abemaciclib Dose Modifications

Grade 1, 2, 3, or 4

Suspend dose and treat as clinically indicated. Abemaciclib may be resumed when the patient is clinically stable.

Abbreviations: CTCAE = Common Terminology Criteria for Adverse Events; VTEs = venous thromboembolic events.

Venous thromboembolic events in monarchE

The Khorana score, summarized in The Khorana Scoring System, was utilized to determine the baseline risk of a venous thromboembolic event (VTE) for patients enrolled in monarchE.2

The Khorana Scoring System3

Patient Characteristics


  • site of cancer (high risk): lung, lymphoma, gynecologic, genitourinary (excluding prostate)

1 point

  • site of cancer (very high risk): stomach, pancreas

2 points

  • platelet count of 350×109/L or more

1 point

  • hemoglobin <10 g/dL and/or use of erythropoiesis-stimulating agents

1 point

  • leukocyte count >11×109/L

1 point

  • body mass index (BMI) >35 kg/m2

1 point

Total combined points

Patients are divided into low risk (0 points), intermediate risk (1-2 points), and high risk (≥3 points) based on the scoring system.3