Tips for searching:
• You have to select a product and type at least 2 words to activate the search
• Use only words that are specific to the information you are looking for
• Avoid typing questions or sentences
Please do not use this field to report adverse events or product complaints. Adverse events and product complaints should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow card in the Google play or Apple app store. Adverse events and product complaints should also be reported to Lilly: please call Lilly UK on 01256 315 000.
Verzenios ® (abemaciclib)
This information is intended for UK registered healthcare professionals only in response to your search for information. For current information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
What is Verzenios® (abemaciclib) recommended dosing and administration?
The recommended dose of abemaciclib is 150 mg twice daily in combination with endocrine therapy.
How Long Should Patients take Abemaciclib?
Early Breast Cancer
Verzenios should be taken continuously for two years, or until disease recurrence or unacceptable toxicity occurs.1
Advanced or Metastatic Breast Cancer
Verzenios should be taken continuously as long as the patient is deriving clinical benefit from therapy or until unacceptable toxicity occurs.1
If a patient vomits or misses a dose of Verzenios, the patient should be instructed to take the next dose at its scheduled time: an additional dose should not be taken.1
How Is Abemaciclib Administered?
Patients should
- take abemaciclib with or without food
- avoid grapefruit or grapefruit juice
- take the doses at the same times every day, and
- swallow the tablet whole.1
When is Abemaciclib Dose Modification Necessary?
Dose modification is recommended based on individual safety and tolerability.
The management of adverse reactions, such as diarrhea, hematologic toxicities, hepatotoxicity, or pneumonitis, may require dose interruption, dose reduction, or both.2
Please find detailed information in the Verzenios Summary of Product Characteristics.1
How is an Abemaciclib Overdose Managed?
Are Dose Modifications Necessary for Patients with Hepatic Impairment
Abemaciclib dose adjustments are only required for patients with severe hepatic impairment (Child-Pugh C). Decrease the dosing frequency to once daily in these patients. 1
No dose adjustments are necessary for patients with mild (Child Pugh A) or moderate (Child Pugh B) hepatic impairment.1
Are Dose Modifications Necessary for Patients with Renal Impairment?
No dose adjustment is required for patients with mild or moderate renal impairment. We have no data in patients with severe impairment or on dialysis.
References
1Verzenios [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
2Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: 28 July 2021