Abasaglar ® (basal insulin glargine)

What is the Half-Life of Abasaglar® (insulin glargine)?

The half-life of Abasaglar is approximately 10 hours.


Results of Phase 1 Clinical Studies 

3 single-site, randomized, double-blind, 2-treatment, 4-period, crossover, euglycemic clamp studies were conducted in healthy subjects to evaluate similarity in the pharmacokinetic (PK) and pharmacodynamic  of

  • Abasaglar
  • the United States (US) - approved version of Lantus, and
  • the European Union (EU) - approved version of Lantus.1

The PK parameter estimates, including half-life, were similar between between Abasaglar and Lantus (Calculated Half-Life for Abasaglar and Lantus After a Single Subcutaneous Dose).1

Calculated Half-Life for Abasaglar and Lantus After a Single Subcutaneous Dose1


Study Drug 
(0.5 units/kg)

Geometric Mean (CV%)


Half-lifea, h


10.0 (59)


US-approved Lantus

11.6 (69)



9.95 (66)


EU-approved Lantus

9.76 (61)


Abbreviations: Abasaglar = Abasaglar® (insulin glargine) 100 units/mL; CV = coefficient of variation; US-approved/EU-approved Lantus = United States-approved/European Union-approved Lantus® (insulin glargine) 100 units/mL.

aHalf-life associated with the terminal rate constant.


1Linnebjerg H, Lam ECQ, Seger ME, et al. Comparison of the pharmacokinetics and pharmacodynamics of LY2963016 insulin glargine and EU- and US-approved versions of Lantus insulin glargine in healthy subjects: three randomized euglycemic clamp studies. Diabetes Care. 2015;38(12):2226-2233. http://dx.doi.org/10.2337/dc14-2623

Date of Last Review: July 24, 2019

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