Taltz ® (ixekizumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

What is the dosing regimen for Taltz® (ixekizumab) in pediatric psoriasis?

160 mg at week 0, then 80 mg every 4 weeks for children greater than 50 kg body weight or 80 mg at week 0, then 40 mg every 4 weeks for children 25-50 kg body weight.


Recommended Pediatric Plaque Psoriasis Dosing Regimen

The recommended dose given by subcutaneous injection in children is based on the following weight categories1

Children’s body weight

Recommended starting dose (week 0)

Recommended dose every 4 weeks (Q4W) thereafter

Greater than 50 kg

160 mg (two 80 mg injections)

80 mg

25 to 50 kg

80 mg

40 mg

Children below 25 kg

Ixekizumab is not recommended for use in children with a body weight below 25 kg. Paediatric body weights must be recorded and regularly re-checked prior to dosing.1

Efficacy and safety data is not available in children below the age of 6 years.1

Available data do not support a posology below a body weight of 25 kg.1

Recommended dose 80 mg

For children prescribed 80 mg, ixekizumab can be used directly from the prefilled syringe.1

Use the Taltz 80 mg pre-filled pen only in those children that require a dose of 80 mg and do not require dose preparation.1

Ixekizumab 40 mg Dose Preparation and Administration for Children 25-50 kg Body Weight

Ixekizumab doses of 40 mg must be prepared and administered by a qualified healthcare professional. Use only Taltz 80 mg solution for injection in pre-filled syringe when preparing the prescribed 40 mg paediatric doses.1

Necessary supplies (not provided with ixekizumab PFS) and dosing preparation steps for pediatric psoriasis patients weighing 25-50 kg are detailed in 

Ixekizumab Dosing Preparation for Pediatric Psoriasis Patients Weighing 50 Kilograms or Less2

The prepared ixekizumab must be administered within 4 hours of puncturing the sterile vial at room temperature.1

Method of Administration

Ixekizumab is for subcutaneous injection. Injection sites may be alternated. If possible, areas of the skin that show psoriasis should be avoided as injection sites. The solution/the syringe must not be shaken.1

After proper training in subcutaneous injection technique, patients may self-inject ixekizumab if a healthcare professional determines that it is appropriate. However, the physician should ensure appropriate follow-up of patients. Comprehensive instructions for administration are given in the package leaflet and the user manual.1

Doses less than 80 mg which require dose preparation should only be administered by a healthcare professional.1

Weight Category Changes

In the IXORA-PEDS clinical trial, if a subject changed weight category, the ixekizumab dose associated with the most current weight was administered for all periods except the 12-week double-blind treatment period.2


1Taltz [summary of product characteristics]. Eli Lilly and Company (Ireland) Limited, Ireland

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.


PFS = prefilled syringe

SC = subcutaneous

Date of Last Review: 14 May 2020

Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at ukmedinfo@lilly.com

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request