Trulicity ® (dulaglutide)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

What information is available about switching between Trulicity® (dulaglutide) and other GLP-1 receptor agonists?

Eli Lilly and Company has not sponsored any studies on the effects of switching between dulaglutide and other glucagon-like peptide-1 receptor agonists (GLP-1 RAs).

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Indication according to the label

Dulaglutide is a Glucagon-like peptide-1 receptor agonist (GLP-1 RA) indicated for once weekly dosing as an adjunct to diet and exercise for the treatment of adults with insufficiently controlled Type 2 Diabetes mellitus.1

What should I consider when switching?

Physicians should follow their clinical judgment, taking into account the patient’s glycemic response and needs, when deciding how to transition from one GLP-1 RA to another one.2 

When transitioning a patient from one GLP-1 RA to another, the prescribing information of the applicable GLP-1 RAs and pharmacokinetic/pharmacodynamic profiles should be considered including

  • dosing and administration
  • safety profile
  • onset of action
  • duration of action
  • half-life
  • time to steady state, and 
  • missed dose information.2

Please find the mentioned pharmacokinetic properties for dulaglutide in Pharmacokinetic properties of dulaglutide . 

Pharmacokinetic properties of dulaglutide 1,2

Onset of action

Improvement in glycemic control starts after the first administration

Duration of action

Improvement in glycemic control is sustained throughout the once-weekly dosing interval

Half-life

Approximately 5 days

Time to steady state

Steady state concentrations are achieved within 2 to 4 weeks.

Missing dosing information

Once steady state is achieved, missing 2 or more consecutive doses may result in subtherapeutic dulaglutide concentrations.

References

1Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 24 January 2022


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