Trulicity ® (dulaglutide)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

What if a Trulicity® (dulaglutide) dose is missed?

If a dose of dulaglutide is missed and there are more than 3 days (72 hours) until the next scheduled dose, it should be administered as soon as possible.

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Instructions for a missed dose of dulaglutide

Dulaglutide is a human glucagon-like peptide-1 receptor agonist for once-weekly administration.1

If patients miss a dulaglutide dose, their next dose depends on how much time there is before the patient's next regularly scheduled injection day (Instructions for a Missed Dose of Dulaglutide).1

Instructions for a Missed Dose of Dulaglutide2

If a dose of dulaglutide is missed and there are…

Then…

And...

at least 72 hours until the next scheduled dose

it should be administered as soon as possible

patients can resume their regular once-weekly dosing schedule.

less than 72 hours remaining before the next scheduled dose

the missed dose should be skipped, the next dose should be administered on the regularly scheduled day,

The day of weekly administration can be changed, as long as the last dulaglutide dose was administered longer than 3 days (72 hours) ago.1

Pharmacokinetics of dulaglutide when a dose is missed

Dulaglutide improves glycemic control after the first dose and maintains the control throughout the once-weekly dosing interval.1

It reaches a steady-state plasma concentration between 2 and 4 weeks following once-weekly administration.1

Once steady state is achieved, missing 2 or more consecutive doses may result in subtherapeutic dulaglutide concentrations (Effect of Missed 1.5 mg Once-Weekly Doses on Dulaglutide Pharmacokinetics at Steady State).1

Effect of Missed 1.5 mg Once-Weekly Doses on Dulaglutide Pharmacokinetics at Steady State1

Figure 1 description: Between the 2nd and 4th dose, dulaglutide reaches its steady-state concentration. When patients missed one dose and took it 3 days before the next regular dose, the dulaglutide concentration was higher in the week of the regular dose, but returned to steady-state when they continued dulaglutide once-weekly. One completely missed dose resulted in lower dulaglutide concentrations, which returned to steady-state in the following 3 weeks when patients resumed once-weekly administration. Two or more consecutive missed doses resulted in even lower dulaglutide concentrations, which may be subtherapeutic, and took longer than 3 weeks to return to steady-state after patients resumed their  once-weekly administration.

References

1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

2Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

Date of Last Review: 02 June 2022


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