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Verzenios ® (abemaciclib)
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Verzenios® (abemaciclib): Effect of Gender on Pharmacokinetics
Gender had no effect on the exposure of Verzenios (abemaciclib).
Detailed Information
Based on a population pharmacokinetic analysis in patients with cancer, gender (135 males and 859 females) had no effect on the exposure of abemaciclib.1
Additional publications further support that abemaciclib exposure is not affected by gender.2-4
Reference
1Data on file, Eli Lilly and Company and/or one of its subsidiaries.
2Tate SC, Sykes AK, Kulanthaivel P, et al. A population pharmacokinetic and pharmacodynamic analysis of abemaciclib in a phase I clinical trial in cancer patients. Clin Pharmacokinet. 2018;57(3):335-344. http://dx.doi.org/10.1007/s40262-017-0559-8
3Chigutsa E, Kambhampati SRP, Sykes AK, et al. Development and application of a mechanistic population modeling approach to describe abemaciclib pharmacokinetics. CPT Pharmacometrics Syst Pharmacol. 2020;9(9):523-533. https://doi.org/10.1002/psp4.12544
4Groenland SL, Martínez-Chávez A, van Dongen MGJ, et al. Clinical pharmacokinetics and pharmacodynamics of the cyclin-dependent kinase 4 and 6 inhibitors palbociclib, ribociclib, and abemaciclib. Clin Pharmacokinet. 2020;59 (12):1501-1520. https://doi.org/10.1007/s40262-020-00930-x
Date of Last Review: 13 January 2022