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Trulicity® (dulaglutide): Switching From Another GLP-1 Receptor Agonist
No studies have been done on the effects of switching from another GLP-1 RA to dulaglutide.
is a GLP-1 RA indicated for once weekly dosing as an adjunct to diet
and exercise for the treatment of adults with unsufficiently
studies have been performed regarding switching to dulaglutide from
another GLP-1 RA.
should follow their clinical judgment, taking into account the
patient’s glycemic control, when deciding how to switch from
one GLP-1 RA to another one.
switching a patient from another GLP-1 RA to dulaglutide, the
prescribing information of the applicable GLP-1 RA and
pharmacokinetic profile should be considered including
to steady state, and
in glycemic control with dulaglutide after the first administration
is sustained throughout the once weekly dosing interval. The
half-life of dulaglutide is approximately 5 days and steady-state
concentrations of dulaglutide are achieved within 2 to 4 weeks.1
Trulicity [summary of product characteristics]. Eli Lilly Nederland
B.V., The Netherlands.
= type 2 diabetes mellitus
RA = glucagon-like peptide-1 receptor agonist
Date of Last Review:October 11, 2018
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