Trulicity® (dulaglutide): Missed Dose Pharmacokinetics

Detailed Information

If a dose is missed, it should be administered as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose.¹

If less than 3 days (72 hours) remain before the next scheduled dose, the missed dose should be skipped and the next dose should be administered on the regularly scheduled day.¹

In each case, patients can then resume their regular once weekly dosing schedule.¹

The day of weekly administration can be changed if necessary, as long as the last dose was administered 3 or more days (72 hours) before.¹

Pharmacokinetics

Improvement in glycemic control can be observed after the first dulaglutide dose and is sustained throughout the once-weekly dosing interval.^1,2

Steady-state plasma concentrations are achieved between 2 and 4 weeks following once-weekly administration.^1,3

Once steady state is achieved, missing 2 or more consecutive doses may result in subtherapeutic dulaglutide concentrations (Figure 1).³

Figure 1. Effect of Missed 1.5 mg Once-Weekly Doses on Dulaglutide Pharmacokinetics at Steady State³

References

1. Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

2. Geiser JS, Heathman MA, Cui X, et al. Clinical pharmacokinetics of dulaglutide in patients with type 2 diabetes: analyses of data from clinical trials. Clin Pharmacokinet. 2016;55(5):625-634. http://rd.springer.com/article/10.1007%2Fs40262-015-0338-3

3. Data on file, Eli Lilly and Company and/or one of its subsidiaries.