Trulicity ® (dulaglutide)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Trulicity Summary of Product Characteristics (SmPC)

Trulicity® (dulaglutide): Missed Dose Pharmacokinetics

If a dose of dulaglutide is missed and there are at least 3 days until the next scheduled dose, it should be administered as soon as possible.

Detailed Information

If a dose is missed, it should be administered as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose.1

If less than 3 days (72 hours) remain before the next scheduled dose, the missed dose should be skipped and the next dose should be administered on the regularly scheduled day.1

In each case, patients can then resume their regular once weekly dosing schedule.1

The day of weekly administration can be changed if necessary, as long as the last dose was administered 3 or more days (72 hours) before.1

Pharmacokinetics

Improvement in glycemic control can be observed after the first dulaglutide dose and is sustained throughout the once-weekly dosing interval.1,2

Steady-state plasma concentrations are achieved between 2 and 4 weeks following once-weekly administration.1,3

Once steady state is achieved, missing 2 or more consecutive doses may result in subtherapeutic dulaglutide concentrations (Figure 1).3

Figure 1. Effect of Missed 1.5 mg Once-Weekly Doses on Dulaglutide Pharmacokinetics at Steady State3

References

1. Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

2. Geiser JS, Heathman MA, Cui X, et al. Clinical pharmacokinetics of dulaglutide in patients with type 2 diabetes: analyses of data from clinical trials. Clin Pharmacokinet. 2016;55(5):625-634. http://rd.springer.com/article/10.1007%2Fs40262-015-0338-3

3. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: January 06, 2020

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