Trulicity ® (dulaglutide)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: (England, Scotland, Wales) or (Northern Ireland).

Trulicity® (dulaglutide): How to use the pen

Keep the base cap on until the dose is ready to be injected. Unlock then pen only after it has been placed against the skin and is ready to be injected. Remove the pen from the skin after a second click has been heard.


Directions for use

Please read the user manual carefully before administering dulaglutide.

The dulaglutide pen is a disposable, pre-filled delivery device that is ready to use. Each pen contains one weekly dose of dulaglutide (either 0.75 mg, 1.5 mg, 3.0 mg or 4.5 mg, respectively) and each pen delivers one dose only.1

Step 1: Uncap

  • Make sure the pen is locked.
  • Pull off and discard the grey base cap.

Do not put the base cap back on – this could damage the needle. Do not touch the needle.1

Step 2: Place and unlock

  • Place the clear base flat and firmly against the skin at the injection site.
  • Unlock by turning the lock ring.1

Step 3: Press and hold

  • Press and hold the green injection button; a loud click will be heard.
  • Continue holding the clear base firmly against the skin until a second click is heard. This occurs when the needle starts retracting in about 5-10 seconds.
  • Remove the pen from the skin.1

Please find below a short video that demonstrates how to use the pen and confirm a dulaglutide injection is complete.

Please click here to watch the video

How to confirm the injection is complete

Do not remove the pen from the skin until the second click is heard. The injection is complete when the grey plunger at the top of the clear base is visible.1,2

Trulicity, Step 3: Press and hold



1Trulicity [instructions for use]. Eli Lilly Nederland B.V., The Netherlands.

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 31 January 2022

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