Taltz ® (ixekizumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

Taltz® (ixekizumab): Can the Patient use Premedication before Injection?

The prescribing physician decides whether to premedicate a patient.


Protocols for Premedication in the Clinical Trials

According to the protocols for psoriasis and psoriatic arthritis, and axSpA (including AS/r-axSpA and nr-axSpA) trials, if a patient experienced an acute allergic/hypersensitivity reaction after injection of investigational product, consideration for any premedication for future injections was agreed upon between the investigator and sponsor and/or its designee.

  • Medications considered appropriate for premedication included but were not restricted to acetaminophen/paracetamol up to 1000 mg and antihistamines (for example, oral diphenhydramine 50 mg), given 30 to 60 minutes prior to investigational product injection.
  • Patients were permitted to self-premedicate at home prior to administration of investigational product as directed by the investigator.1,2

Examples of potential allergic/hypersensitivity reactions that might merit premedication included

  • mild-to-moderate skin rashes
  • mild-to-moderate generalized pruritus or urticaria, and
  • mild-to-moderate ISRs (eg, injection-site erythema, injection-site pruritus, etc).1,2

Please note that ixekizumab is contraindicated in patients with serious hypersensitivity to the active substance or to any of the excipients.3

Premedication in Clinical Trials

Of patients experiencing an ISR during the induction period of UNCOVER-1, -2, and -3, one patient who received ixekizumab used premedication for ISR when taking future injections.2

No patients who received ixekizumab during the 24-week double-blind treatment periods of SPIRIT-P1 and SPIRIT-P2 used premedication for ISR with future injections.2

No analysis has been conducted on patients who used premedication for ISR with future injections in axSpA trials.


1Gordon KB, Blauvelt A, Papp KA, et al; UNCOVER-1, UNCOVER-2, and UNCOVER-3 Study Groups. Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. N Engl J Med. 2016;375(4):345-356. http://dx.doi.org/10.1056/NEJMoa1512711

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.

3Taltz [summary of product characteristics]. Eli Lilly and Company (Ireland) Limited, Ireland


AS/r-axSpA = ankylosing spondylitis/radiographic axial spondyloarthritis

axSpA = axial spondyloarthritis

ISR = injection site reaction

nr-axSpA = nonradiographic axial spondyloarthritis

Date of Last Review: 25 September 2020

Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at ukmedinfo@lilly.com

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request