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Atomoxetine is not a psychostimulant and is not an amphetamine derivative
a randomised, double-blind, placebo-controlled, abuse-potential study
in adults comparing effects of atomoxetine and placebo, atomoxetine
was not associated with a pattern of response that suggested
stimulant or euphoriantproperties.
is a highly selective and potent inhibitor of the pre-synaptic
noradrenaline transporter, its presumed mechanism of action, without
directly affecting the serotonin or dopamine transporters.
Atomoxetine has minimal affinity for other noradrenergic receptors or
for other neurotransmitter transporters or receptors. Atomoxetine has
two major oxidative metabolites: 4-hydroxyatomoxetine and
is equipotent to atomoxetine as an inhibitor of the noradrenaline
transporter but, unlike atomoxetine, this metabolite also exerts some
inhibitory activity at the serotonin transporter. However, any
effect on this transporter is likely to be minimal, as the majority
of 4-hydroxyatomoxetine is further metabolised such that it
circulates in plasma at much lower concentrations (1% of atomoxetine
concentration in extensive metabolisers and 0.1% of atomoxetine
concentration in poor metabolisers).
has substantially less pharmacological activity compared with
atomoxetine. It circulates in plasma at lower concentrations in
extensive metabolisers and at comparable concentrations to the parent
drug in poor metabolisers at steady-state.
Summary of Product Characteristics
Date of Last Review:November 02, 2018
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