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Olumiant ® ▼ (baricitinib)
Olumiant® ▼ (baricitinib): Laboratory Monitoring
Neutrophil, lymphocyte, hemoglobin, and hepatic transaminases levels should be assessed prior to initiation of baricitinib, and lipids should be assessed 12 weeks after initiation.
Laboratory Monitoring with Baricitinib Treatment
For information on laboratory monitoring with baricitinb treatment please see Table 1.
Table 1. Laboratory measures and monitoring guidance1
|
Laboratory Measure |
Action |
Monitoring Guidance |
|
Lipid parameters |
Patients should be managed according to international clinical guidelines for hyperlipidaemia |
12 weeks after initiation of treatment and thereafter according to international clinical guidelines for hyperlipidaemia |
|
Absolute Neutrophil Count (ANC) |
Treatment should be interrupted if ANC < 1 x 109 cells/L and may be restarted once ANC return above this value |
Before treatment initiation and thereafter according to routine patient management |
|
Absolute Lymphocyte Count (ALC) |
Treatment should be interrupted if ALC < 0.5 x 109 cells/L and may be restarted once ALC return above this value |
|
|
Haemoglobin (Hb) |
Treatment should be interrupted if Hb < 8 g/dL and may be restarted once Hb return above this value |
|
|
Hepatic transaminases |
Treatment should be temporarily interrupted if drug-induced liver injury is suspected |
Please refer to section 4.4 of the Olumiant Summary of Product Characteristics for further information on special warnings and precautions for use with baricitinib.
1. Olumiant [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
Glossary
ALC = absolute lymphocyte count
ANC = absolute neutrophil count
BARI = baricitinib
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.
Date of Last Review: November 13, 2020
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