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Olumiant ® (baricitinib)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
Olumiant® (baricitinib): Laboratory Monitoring
Neutrophil, lymphocyte, hemoglobin, and hepatic transaminases levels should be assessed prior to initiation of baricitinib, and lipids should be assessed 12 weeks after initiation.
UK_cFAQ_BAR104_MONITORING_LABORATORY_TESTS_RA_AD
en-GB
Laboratory Monitoring with Baricitinib Treatment
For information on laboratory monitoring with baricitinb treatment please see Laboratory measures and monitoring guidance.
Laboratory Measure |
Action |
Monitoring Guidance |
Lipid parameters |
Patients should be managed according to international clinical guidelines for hyperlipidaemia |
12 weeks after initiation of treatment and thereafter according to international clinical guidelines for hyperlipidaemia |
Absolute Neutrophil Count (ANC) |
Treatment should be interrupted if ANC < 1 x 109 cells/L and may be restarted once ANC return above this value |
Before treatment initiation and thereafter according to routine patient management |
Absolute Lymphocyte Count (ALC) |
Treatment should be interrupted if ALC < 0.5 x 109 cells/L and may be restarted once ALC return above this value |
|
Haemoglobin (Hb) |
Treatment should be interrupted if Hb < 8 g/dL and may be restarted once Hb return above this value |
|
Hepatic transaminases |
Treatment should be temporarily interrupted if drug-induced liver injury is suspected |
Please refer to section 4.4 of the Olumiant Summary of Product Characteristics for further information on special warnings and precautions for use with baricitinib.
References
1Olumiant [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
Glossary
ALC = absolute lymphocyte count
ANC = absolute neutrophil count
BARI = baricitinib
Date of Last Review: 13 November 2020
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