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Lyumjev ® ▼ (insulin lispro)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information:
Lyumjev Summary of Product Characteristics (SmPC)
Lyumjev® ▼ (insulin lispro): Treprostinil and Drug-drug Interaction
In the absence of systemic effect, no Lyumjev drug-drug interaction studies are required.
- Drug-Drug Interaction
have agreed that no drug-drug interaction studies are required.1
the formulation of Lyumjev, microdoses of treprostinil are used
as an excipient to increase blood flow at the site of injection
through localized vasodilation.2-4
commercial formulation of Lyumjev contains 10 ng of treprostinil per
unit of insulin lispro in a 100 unit/mL formulation.1
dose of 10 ng of treprostinil does not show detectable circulating
levels, and no systemic effects are shown.1
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Leohr J, Pratt E, Heilmann C, et al. Treprostinil causes local
vasodilation is well tolerated, and results in faster absorption of
insulin lispro [abstract]. Diabetologia. 2017;60(suppl
Leohr J, Pratt EJ, Heilmann C, et al. A novel insulin lispro
formulation containing citrate and treprostinil demonstrates faster
absorption and onset of insulin action in healthy subjects
[abstract]. Diabetes. 2017;66(suppl 1):A253.
Pratt E, Leohr J, Heilmann C, et al. Treprostinil causes local
vasodilation, is well tolerated, and results in faster absorption of
insulin lispro [abstract]. Diabetes. 2017;66(suppl 1):A253.
medicinal product is subject to additional monitoring. This will
allow quick identification of new safety information. Healthcare
professionals are asked to report any suspected adverse reactions.
Date of Last Review:July 19, 2019
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