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Lyumjev Summary of Product Characteristics (SmPC)
Lyumjev® ▼ (insulin lispro): Citrate and Effect as Excipient
Citrate is an excipient in Lyumjev formulation that acts to increase vascular permeability.
Lyumjev
- Citrate in Formulation
Sodium
citrate is an excipient that acts to increase vascular permeability,
resulting in the accelerated absorption of insulin lispro.1-4
Citrate
is a common GRAS ingredient used in many pharmaceutical
formulations.5-7
References
1.
Leohr J, Pratt EJ, Heilmann C, et al. A novel insulin lispro
formulation containing citrate and treprostinil demonstrates faster
absorption and onset of insulin action in healthy subjects
[abstract]. Diabetes. 2017;66(suppl 1):A253. American Diabetes
Association abstract 976‑P.
http://dx.doi.org/10.2337/db17-890-1488
2.
Michael MD, Zhang C, Siesky AM, et al. Exploration of the Mechanism
of Accelerated Absorption for a Novel Insulin Lispro Formulation
[abstract]. Diabetes. 2017;66(suppl 1):A250.
http://dx.doi.org/10.2337/db17-890-1488
3.
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
4.
Lyumjev [summary of product characteristics]. Eli Lilly Nederland
B.V., The Netherlands.
▼ This
medicinal product is subject to additional monitoring. This will
allow quick identification of new safety information. Healthcare
professionals are asked to report any suspected adverse reactions.
Date of Last Review:August 06, 2019
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