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Verzenios ® ▼ (abemaciclib)
Is Verzenios® ▼ (abemaciclib) dose adjustment required for patients with hepatic impairment?
Abemaciclib dose adjustments are only required for patients with with severe hepatic impairment (Child-Pugh C). Decrease the dosing frequency to once daily in these patients.
UK_cFAQ_ABE013_Z2_HEPATIC_IMPAIRMENT
en-GB
Relative Potency and Half-Life of Abemaciclib increases in Patients with Severe Hepatic Impairment
No dose adjustments are necessary in patients with mild (Child Pugh A) or moderate (Child Pugh B) hepatic impairment.1
Abemaciclib is metabolised in the liver.
Mild (Child Pugh A) and moderate (Child Pugh B) hepatic impairment had no effect on the exposure of abemaciclib. In severe hepatic impairment (Child Pugh C), the potency adjusted unbound abemaciclib plus its active metabolites increased 2.4-fold. The half‑life of abemaciclib increased from 24 to 55 hours.1
References
1Verzenios [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.
Date of Last Review: October 23, 2019
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