Cyramza ® (ramucirumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: (England, Scotland, Wales) or (Northern Ireland).

Is Cyramza® (ramucirumab) compatible with large-bore needles or spikes?

The use of large-bore needles can cause coring of the stopper and is therefore not recommended.


Use of large-bore needles/spikes

The use of large-bore needles or “spikes” has not been tested by Eli Lilly and Co. and is therefore not recommended. 

The large bore can cause coring and fragmentation of the stopper. 

If the use of spikes cannot be prevented, inspect the diluted solution for particles and discolouration before administration. Discard the solution if you see particles or discolouration.1

Cyramza vials contain chlorobutyl elastomer stoppers that are intended for single use. The stoppers are easy to penetrate with a sharp needle.1 


1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 24 March 2022

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