IV infusion, using Humulin S, is a method of insulin delivery
specifically for use in hospitalized patients.1-3
IV use, Humulin S may be administered under medical supervision with
close monitoring of BG and potassium levels to avoid hypoglycemia and
administered IV in doses ranging from 0.1 to 0.2 units/kg, the
pharmacologic effect of Humulin S
approximately 10 to 15 minutes after administration, and
approximately 4 hours (range: 2-6 hours) after administration.4
IV insulin infusions are mixed to a concentration of 1 unit/mL in
normal saline and infused into a dedicated IV line. If the patient
requires volume restriction, a more concentrated solution may be
and Stability in IV Bags
IV use, Humulin S can be diluted at
from 0.1 to 1 unit/mL
0.9% sodium chloride solution for injection.4
bags prepared with Humulin S are stable when
in a refrigerator (2°C to 8°C) for 48 hours and then
be used at room temperature for up to an additional 48 hours.4
of IV Sets
priming of IV sets to accommodate the adsorption of insulin is
included in several institutional protocols.5-7
study designed to quantify the insulin adsorption losses to IV lines
100 units of Humulin S to each of 20 polyvinyl bags containing 100
mL of 0.9% sodium chloride for injection
the resultant solutions (1 unit/mL) through standard polypropylene
infusion sets, and
samples at 10-mL intervals from 0 to 50 mL.
authors concluded that, for standard IV insulin infusions, a priming
volume of 20 mL was sufficient to minimize the effect of insulin
adsorption losses to IV lines.7
American Diabetes Association. 15. Diabetes Care in the Hospital:
Standards of Medical Care in Diabetes-2020. Diabetes Care.
2020;43(suppl 1):S193-S202. https://dx.doi.org/10.2337/dc20-S015
Clement S, Braithwaite SS, Magee MF, et al. Diabetes in Hospitals
Writing Committee. Management of diabetes and hyperglycemia in
hospitals. Diabetes Care. 2004;27(2):553-591.
Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association
of Clinical Endocrinologists and American Diabetes Association
consensus statement on inpatient glycemic control. Endocr Pract.
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Quevedo SF, Sullivan E, Kington R, Rogers W. Improving diabetes care
in the hospital using guideline-directed orders. Diabetes Spectr.
Goldberg PA, Roussel MG, Inzucchi SE. Clinical results of an updated
insulin infusion protocol in critically ill patients. Diabetes
Goldberg PA, Kedves A, Walter K, et al. “Waste not, want not”:
determining the optimal priming volume for intravenous insulin
infusions. Diabetes Technol Ther. 2006;8(5):598-601.
= diabetic ketoacidosis
= type 1 diabetes mellitus
= type 2 diabetes mellitus