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Humatrope® (somatropin): Interaction with other medicinal products
Humatrope (somatropin) may interact with other medicines
with diabetes mellitus who receive concomitant somatropin may require
adjustment of their doses of insulin and/or other anti-hyperglycaemic
treatment with glucocorticoids inhibits the growth-promoting effects
of somatropin. Patients with ACTH deficiency should have their
glucocorticoid replacement therapy carefully adjusted to avoid any
inhibitory effect on growth. Growth hormone decreases the conversion
of cortisone to cortisol and may unmask previously undiscovered
central hypoadrenalism or render low glucocorticoid replacement doses
women on oral oestrogen replacement, a higher dose of growth hormone
may be required to achieve the treatment goal.
can increase cytochrome P450 (CYP) enzyme activity in humans and may
result in reduced plasma concentrations and decreased effectiveness
of drugs metabolised by CYP3A such as sex steroids, corticosteroids,
Summary of Product Characteristics
Date of Last Review:April 05, 2019
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