Humatrope ® (somatropin)

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Humatrope® (somatropin): Interaction with other medicinal products

Humatrope (somatropin) may interact with other medicines

Patients with diabetes mellitus who receive concomitant somatropin may require adjustment of their doses of insulin and/or other anti-hyperglycaemic agents.

Concomitant treatment with glucocorticoids inhibits the growth-promoting effects of somatropin. Patients with ACTH deficiency should have their glucocorticoid replacement therapy carefully adjusted to avoid any inhibitory effect on growth. Growth hormone decreases the conversion of cortisone to cortisol and may unmask previously undiscovered central hypoadrenalism or render low glucocorticoid replacement doses ineffective.

In women on oral oestrogen replacement, a higher dose of growth hormone may be required to achieve the treatment goal.

Somatropin can increase cytochrome P450 (CYP) enzyme activity in humans and may result in reduced plasma concentrations and decreased effectiveness of drugs metabolised by CYP3A such as sex steroids, corticosteroids, cyclosporine and anticonvulsants.


Humatrope Summary of Product Characteristics

Date of Last Review: 04 April 2022

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