necessary, IL-100 may be administered IV, for example for the control
of blood glucose levels during :
is available in vials if administration of IV injection is
injection of IL-100 should be carried out following normal clinical
practise for IV injections, for example by an IV bolus or by an
Stability and Adsorption
systems at concentrations from 0.1 units/ml to 1.0 units/ml insulin
lispro in 0.9 % sodium chloride or 5 % dextrose are stable at room
temperature for 48 hours. 1
study that investigated the potential adsorption of IL-100 to IV
infusion sets and syringes found that,
glass beakers, solutions of IL-100 diluted with 0.9% sodium chloride
and 5% dextrose to concentrations of 0.25 to 2 units/mL and 0.025 to
0.2 units/mL were stable for 48 hours at room temperature, and
both bags and syringes at concentrations of 0.1 and 1 units/mL, the
adsorption profile of IL-100 was the same as that of Humulin S.
both Humulin S and IL-100, the percent expected delivery rates were
steady after an initial lag time.
study found several ways to substantially decrease the lag time,
specifically higher product concentration, prewash of the infusion
tubing, and faster flow rate.2
of IV Sets
is recommended that the system is primed before starting the infusion
to the patient.1
priming of IV sets to accommodate the adsorption of insulin is
included in several institutional protocols.3-5
study designed to quantify the insulin adsorption losses to IV lines
100 units of Humulin S to each of 20 polyvinyl bags containing 100
mL of 0.9% sodium chloride for injection
the resultant solutions (1 unit/mL) through standard polypropylene
infusion sets, and
samples at 10-mL intervals from 0 to 50 mL.
authors concluded that, for standard IV insulin infusions, a priming
volume of 20 mL was sufficient to minimize the effect of insulin
adsorption losses to IV lines.5
Humalog [summary of product characteristics]. Eli Lilly Nederland
B.V., The Netherlands.
Ung J, Hu M, Hagerup T, Campbell RK. Lispro insulin: adsorption and
stability in selected intravenous devices. Diabetes Educ.
Quevedo SF, Sullivan E, Kington R, Rogers W. Improving diabetes care
in the hospital using guideline-directed orders. Diabetes Spectr.
Goldberg PA, Roussel MG, Inzucchi SE. Clinical results of an updated
insulin infusion protocol in critically ill patients. Diabetes
Goldberg PA, Kedves A, Walter K, et al. “Waste not, want not”:
determining the optimal priming volume for intravenous insulin
infusions. Diabetes Technol Ther. 2006;8(5):598-601.
= Humalog® (insulin lispro) 100 units/mL