Trulicity ® (dulaglutide)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Trulicity Summary of Product Characteristics (SmPC)

How should other medications be administered with Trulicity® (dulaglutide)?

Consider reducing insulin/insulin secretagogue dose when initiating Trulicity (dulaglutide). Dulaglutide may reduce absorption of orally co-administered drugs.

Detailed Information

Potential for Dulaglutide to Influence the Pharmacokinetics of Other Drugs

Dulaglutide slows gastric emptying and, as a result, may reduce the extent and rate of absorption of orally coadministered medications.1

In clinical pharmacology studies, treatment with dulaglutide did not affect, to any clinically relevant degree, the absorption of coadministered oral medications that included

  • lisinopril

  • warfarin

  • metoprolol

  • digoxin

  • norelgestromin

  • ethinylestradiol

  • atorvastatin

  • metformin

  • paracetamol, and

  • sitagliptin.1

No dose adjustment is recommended for any of these evaluated coadministered medications.1

Concomitant Use With an Insulin Secretagogue or With Insulin

To reduce the risk of hypoglycemia when initiating dulaglutide treatment, consider reducing the dosage of concomitantly administered

  • insulin secretagogues, such as sulfonylureas, or

  • insulin.1

References

1. Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

Date of Last Review: July 13, 2020

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