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Abasaglar ® (basal insulin glargine)
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How long does it Take for Abasaglar® (insulin glargine) to Start Working?
The median onset of action for Abasaglar is approximately 1 to 2 hours.
UK_cFAQ_BIV048_ONSET
en-GB
Onset of Action
The onset of action for Abasalar
- varies with dose and among patient populations, and
- is expected to be shorter for patients with diabetes mellitus compared with healthy subjects.1
Additional Information in Healthy Subjects
3 single-site, randomized, double-blind, 2-treatment, 4-period, crossover, euglycemic clamp studies were conducted in healthy subjects to evaluate similarity in the pharmacokinetic and pharmacodynamic of
- Abasaglar (insulin glargine) 100 units/mL
- the United States (US) - approved version of Lantus (insulin glargine) 100 units/mL, and
- the European Union (EU) - approved version of Lantus.2
The median onset of action, defined as the time of first change of glucose infusion rate postdose, was similar between study groups and ranged from
- 0.81 to 2.10 hours for Abasaglar
- 1.70 to 1.87 hours for the US-approved version of Lantus, and
- 0.83 to 2.13 hours for the EU-approved version of Lantus.2
References
1Data on file, Eli Lilly and Company and/or one of its subsidiaries.
2Linnebjerg H, Lam ECQ, Seger ME, et al. Comparison of the pharmacokinetics and pharmacodynamics of LY2963016 insulin glargine and EU- and US-approved versions of Lantus insulin glargine in healthy subjects: three randomized euglycemic clamp studies. Diabetes Care. 2015;38(12):2226-2233. http://dx.doi.org/10.2337/dc14-2623
Date of Last Review: 13 July 2022
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