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Cyramza ® (ramucirumab)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
How do I manage extravasation with Cyramza® (ramucirumab)?
If extravasation occurs or is suspected, follow your local procedures for managing non-vesicant extravasation or use local cold compresses.
Recommendations from the European Society for Medical Oncology - The European Oncology Nursing Society (ESMO-EONS)
The European Society for Medical Oncology-The European Oncology Nursing Society (ESMO-EONS) Clinical Practice Guidelines recommend using local dry cold compresses for non-vesicants such as ramucirumab if extravasation does occur.1
Cyramza is not a vesicant
Ramucirumab is a non-vesicant as it is an antibody in a neutral formulation. It is not likely to cause extravasation.
No dedicated extravasation studies have been conducted in animals. However, local tolerance was investigated in 2 repeat-dose toxicity evaluations in cynomolgus monkeys by clinical observations and as part of the histopathological evaluations.
Intravenous administration of ramucirumab was well tolerated at all dose levels.
Mild, local injection-site reactions were observed and consisted of mononuclear and/or polymorphonuclear cells in the perivascular areas.2
1Perez Fidalgo JA, Garcia Fabregat L, Cervantes A, et al. Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Ann Oncol. 2012;Suppl 7:vii167-73. http://annonc.oxfordjournals.org/content/23/suppl_7/vii167
2Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: 07 August 2019