Cyramza ® (ramucirumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: (England, Scotland, Wales) or (Northern Ireland).

How do I manage extravasation with Cyramza® (ramucirumab)?

If extravasation occurs or is suspected, follow your local procedures for managing non-vesicant extravasation or use local cold compresses.


Recommendations from the European Society for Medical Oncology - The European Oncology Nursing Society (ESMO-EONS)

The European Society for Medical Oncology-The European Oncology Nursing Society (ESMO-EONS) Clinical Practice Guidelines recommend using local dry cold compresses for non-vesicants such as ramucirumab if extravasation does occur.1

Cyramza is not a vesicant

Ramucirumab is a non-vesicant as it is an antibody in a neutral formulation. It is not likely to cause extravasation. 

No dedicated extravasation studies have been conducted in animals. However, local tolerance was investigated in 2 repeat-dose toxicity evaluations in cynomolgus monkeys by clinical observations and as part of the histopathological evaluations.

Intravenous administration of ramucirumab was well tolerated at all dose levels.

Mild, local injection-site reactions were observed and consisted of mononuclear and/or polymorphonuclear cells in the perivascular areas.2


1Perez Fidalgo JA, Garcia Fabregat L, Cervantes A, et al. Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Ann Oncol. 2012;Suppl 7:vii167-73.

2Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 25 April 2022

Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request