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Forsteo ® (teriparatide)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).
Forsteo® (teriparatide): Patients with History of Cancer
Patients with skeletal malignancies or bone metastases should be excluded from treatment with teriparatide.
In a patient with a history of cancer, take into consideration the type of previous cancer, the risk of bone metastases, and the length of time the patient has been in remission before prescribing Forsteo.1
Relevant Information from Summary of Product Characteristics
Patients with skeletal malignancies or bone metastases should be excluded from treatment with teriparatide (contraindication).2
Forsteo is contraindicated in patients with prior external beam or implant radiation therapy to the skeleton.2
Types of Common Cancer that Metastasize to the Bone
Common cancers that metastasize to the bone, in decreasing order of frequency, include1
Information from Clinical Studies
Patients with a history of carcinoma in the previous five years or with a current suspicion were excluded from participating in clinical trials with teriparatide. However, patients with excised superficial lesions of the skin and those with a history of carcinoma in situ of the cervix or uterus were allowed to participate.3
There was no apparent increase in the incidence of cancers among all study participants treated with teriparatide compared with placebo during clinical trials.3
1. File E, Deal C. Clinical update on teriparatide. Curr Rheumatol Rep. 2009;11(3):169-176. http://link.springer.com/article/10.1007/s11926-009-0023-3
3. Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: 03 March 2020