Emgality ® ▼ (galcanezumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Emgality Summary of Product Characteristics (SmPC)

Emgality® ▼ (galcanezumab): Use in Patients With COVID-19 (Coronavirus Disease 2019)

The use of galcanezumab in patients with COVID-19 has not been studied.

Use of Galcanezumab in Patients With COVID-19

Coronavirus disease 2019 is an infectious respiratory disease caused by SARS-CoV-2, previously referred to as "2019 novel coronavirus."1,2

Eli Lilly and Company has not studied the use of galcanezumab in patients with COVID-19.

Clinicians should use their clinical judgment in determining the most appropriate approach in treating a patient with galcanezumab who has confirmed or suspected COVID-19.

CGRP mAbs Have no Direct Specific Immunomodulatory Effect

The CGRP mAbs have been engineered to bind to either the CGRP peptide or receptor with high specificity and minimized interaction with the immune system.3-5 As CGRP is not an immune system target, CGRP mAbs have no direct immunomodulatory effect.

The use of galcanezumab is not associated with increased risk of infections or immunosuppression, nor are such events identified as important risks in the galcanezumab risk management plan.6

Published Literature Related to Use of CGRP Monoclonal Antibody Therapy in a Patient With COVID-19

There is limited published literature on the management of patients with migraine and COVID-19. As of the last revision date, the Spanish Society of Neurology's Headache Study Group has published their opinion that the currently available data do not suggest that interruption to standard headache therapies is warranted.7 In an editorial published in Headache, the authors recommend the use of migraine preventive therapies, which include CGRP mAbs, that allow for management of the patient in a telehealth setting.8

Infectious Disease Resources

For the most current information regarding the coronavirus, please refer to the WHO website:

WHO Coronavirus disease (COVID-19) outbreak

References

1. Naming the coronavirus disease (COVID-19) and the virus that causes it. World Health Organization. Accessed November 10, 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it

2. Coronavirus. World Health Organization. Accessed November 10, 2020. https://www.who.int/health-topics/coronavirus#tab=tab_1

3. Raffaelli B, Reuter U. The biology of monoclonal antibodies: focus on calcitonin gene-related peptide for prophylactic migraine therapy. Neurotherapeutics. 2018;15(2):324-335. http://dx.doi.org/10.1007/s13311-018-0622-7

4. Silberstein S, Lenz R, Xu C. Therapeutic monoclonal antibodies: what headache specialists need to know. Headache. 2015;55(8):1171-1182. http://dx.doi.org/10.1111/head.12642

5. Levin M, Silberstein SD, Gilbert R, et al. Basic considerations for the use of monoclonal antibodies in migraine. Headache. 2018;58(10):1689-1696. http://dx.doi.org/10.1111/head.13439

6. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

7. Morollón N, Belvís R, De Dios A, et al. Standard headache and neuralgia treatments and SARS-CoV-2: opinion of the Spanish Society of Neurology's Headache Study Group. Neurología. 2020;35(9):628-632. http://dx.doi.org/10.1016/j.nrl.2020.07.007

8. Szperka CL, Ailani J, Barmherzig R, et al. Migraine care in the era of COVID-19: clinical pearls and plea to insurers. Headache. 2020;60(5):833-842. http://dx.doi.org/10.1111/head.13810

Glossary

CGRP = calcitonin gene-related peptide

COVID-19 = coronavirus disease 2019

mAb = monoclonal antibody

SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2

WHO = World Health Organization

This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.

Date of Last Review: November 03, 2020


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