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Trulicity ® (dulaglutide)
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Does Trulicity® (dulaglutide) have an effect on pancreatic enzyme levels?
In the 9 registration clinical studies, dulaglutide treatment increased pancreatic enzymes. The changes in pancreatic enzymes were dose dependent and greater for dulaglutide 1.5 mg than dulaglutide 0.75 mg.
cFAQ
cFAQ
UK_cFAQ_GLP055_Z3_EFFECT_PANCREATIC_ENZYMES
en-GB
What changes in lipase and p-amylase levels were seen with dulaglutide?
The median changes in lipase ranged from
- 5.0 to 7.0 units/L with dulaglutide 1.5 mg, and
- 3.0 to 5.0 units/L with dulaglutide 0.75 mg.
Median levels in lipase also increased with sitagliptin, exenatide twice daily, and metformin. A small decrease in the median level in lipase was noted with Insulin glargine. A small decrease to no change was noted with placebo.1
The median changes in p-amylase ranged from
- 3.0 to 5.0 units/L with dulaglutide 1.5 mg, and
- 2.0 to 4.0 units/L with dulaglutide 0.75 mg.
Median levels in p-amylase also increased with sitagliptin, exenatide twice daily, metformin, and Insulin glargine. The median level in p-amylase did not change with placebo.1
References
1Nauck MA, Frossard JL, Barkin JS, et al. Assessment of pancreas safety in the development program of once-weekly GLP-1 receptor agonist dulaglutide. Diabetes Care. 2017;40(5):647-654. http://dx.doi.org/10.2337/dc16-0984
Date of Last Review: 05 October 2020
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