Trulicity ® (dulaglutide)

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Does Trulicity® (dulaglutide) have an effect on pancreatic enzyme levels?

In the 9 registration clinical studies, dulaglutide treatment increased pancreatic enzymes. The changes in pancreatic enzymes were dose dependent and greater for dulaglutide 1.5 mg than dulaglutide 0.75 mg.


What changes in lipase and p-amylase levels were seen with dulaglutide?

The median changes in lipase ranged from

  • 5.0 to 7.0 units/L with dulaglutide 1.5 mg, and
  • 3.0 to 5.0 units/L with dulaglutide 0.75 mg.

Median levels in lipase also increased with sitagliptin, exenatide twice daily, and metformin. A small decrease in the median level in lipase was noted with Insulin glargine. A small decrease to no change was noted with placebo.1

The median changes in p-amylase ranged from

  • 3.0 to 5.0 units/L with dulaglutide 1.5 mg, and
  • 2.0 to 4.0 units/L with dulaglutide 0.75 mg.

Median levels in p-amylase also increased with sitagliptin, exenatide twice daily, metformin, and Insulin glargine. The median level in p-amylase did not change with placebo.1

4 weeks after patients discontinued dulaglutide treatment, increased pancreatic enzymes returned to near baseline levels. 1 

Routine pancreatic enzyme testing in asymptomatic patients in the clinical setting had limited clinical value and did not predict the onset of acute pancreatitis.1


1Nauck MA, Frossard JL, Barkin JS, et al. Assessment of pancreas safety in the development program of once-weekly GLP-1 receptor agonist dulaglutide. Diabetes Care. 2017;40(5):647-654.

Date of Last Review: 05 October 2020

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