Taltz ® (ixekizumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

Does Taltz® (ixekizumab) affect fertility?

The effect of ixekizumab on human fertility has not been evaluated. Animal studies do not indicate direct or indirect harmful effects with respect to fertility.

UK_cFAQ_IXE009_X3_FERTILITY_PsO_PsA_axSpA
cFAQ
cFAQ
UK_cFAQ_IXE009_X3_FERTILITY_PsO_PsA_axSpA
en-GB

What are the data on ixekizumab and fertility?

Nonclinical data from reproductive and developmental toxicity studies performed with ixekizumab on cynomolgus monkeys revealed no special hazards for humans.1

No effects were observed in sexually mature cynomolgus monkeys that received ixekizumab for 13 weeks at a weekly subcutaneous dose of 50 mg/kg (at least 19 times the 160-mg starting dose of ixekizumab) regarding

  • reproductive organs
  • menstrual cycles, or
  • sperm (including sperm count and morphology).1

The monkeys were not mated to evaluate fertility and pregnancy outcomes.2

References

1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

2Clarke DO, Hilbish KG, Waters DG, et al. Assessment of ixekizumab, an interleukin-17A monoclonal antibody, for potential effects on reproduction and development, including immune system function, in cynomolgus monkeys. Reprod Toxicol. 2015;58:160-173. http://dx.doi.org/10.1016/j.reprotox.2015.10.008

Date of Last Review: 09 November 2021


Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at ukmedinfo@lilly.com

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request