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Cyramza ® (ramucirumab)
Cyramza® (ramucirumab): Use in patients with COVID-19 (Coronavirus disease 2019)
The use of Cyramza (ramucirumab) in patients with COVID-19 has not been studied.
Ramucirumab Treatment and Coronavirus (COVID-19)
COVID-19 is an infectious respiratory disease caused by SARS-CoV-2, previously referred to as "2019 novel coronavirus."1
Eli Lilly and Company has not studied the use of ramucirumab in patients with COVID-19 nor specifically in patients at risk of contracting COVID-19.
Potential Risk and Benefit Considerations
Treating physicians should assess the patient’s individual benefit/risk ratio considering the patient's signs and symptoms, prior medical history, concomitant medications, and other individual factors when making ramucirumab treatment decisions in the context of COVID-19. Ramucirumab dose adjustments, made at the physician’s discretion, should follow the label. Supportive treatment should be provided as clinically indicated and patients monitored appropriately. Drug interactions between ramucirumab and potential COVID-19 treatments should be considered and are described below.2
Drug Interactions
The following medications are not expected to have a clinically relevant effect on ramucirumab exposure and ramucirumab is not expected to have a clinically relevant effect on the exposure of the following potential-COVID-19 medications
hydroxychloroquine
chloroquine
remdesivir
favipiravir
ritonavir
lopinavir, or
azithromycin.2
Infectious Disease Resources for COVID-19
For the most current information regarding COVID-19, please refer to the following resources:
Coronavirus disease (COVID-19) outbreak on the regional office of the EU WHO
COVID-19 on the ECDC web page.
European Society for Medical Oncology (ESMO)
Coronavirus (COVID-19) National Institute for Health and Care Excellence (NICE).3-6
1. Naming the coronavirus disease (COVID-19) and the virus that causes it. World Health Organization. Accessed March 17, 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it
2. Data on file, Eli Lilly and Company and/or one of its subsidiaries.
3. Coronavirus disease (COVID-19) outbreak. World Health Organization Europe. Accessed March 20, 2020. http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/novel-coronavirus-2019-ncov
4. COVID-19. European Centre for Disease Prevention and Control. Accessed March 20, 2020. https://www.ecdc.europa.eu/en/novel-coronavirus-china
5. European Society for Medical Oncology. Accessed March 23th. https://www.esmo.org/newsroom/covid-19-and-cancer/covid-19-useful-resources
6. [NICE] National Institute for Health and Care Excellence. Coronavirus (COVID-19). Available from: https://www.nice.org.uk/covid-19. Accessed 25 March 2020.
Glossary
CDC = Centers for Disease Control and Prevention
COVID-19 = coronavirus disease 2019
NCCN = National Comprehensive Cancer Network
SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2
WHO = World Health Organization
Date of Last Review: March 17, 2020
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