Cyramza ® (ramucirumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Cyramza Summary of Product Characteristics (SmPC)

Cyramza® (ramucirumab): Storage and Stability of Vials In Use

From a microbiological point of view, ramucirumab should be used immediately. Storage prior to use is the responsibility of the user. Chemical and physical in-use stability has been demonstrated for 24 hours at 2 ºC to 8 ºC or for 4 hours at 25 ºC.

Further information

The infusion solution should be prepared using aseptic technique to ensure the sterility of the prepared solution.1

When prepared as directed, infusion solutions of ramucirumab contain no antimicrobial preservatives.1

Chemical and physical in-use stability of ramucirumab in sodium chloride 9 mg/ml (0.9%) solution for injection has been demonstrated for 24 hours at 2 ºC to 8 ºC or for 4 hours at 25 ºC. From a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2 ºC to 8 ºC, unless dilution has taken place in controlled and validated aseptic conditions.1

The infusion solution should not be frozen or shaken.1

Parenteral medicinal products should be inspected visually for particulate matter prior to administration. If particulate matter is identified, the infusion solution should be discarded.1

Any unused portion of ramucirumab left in a vial should be discarded, as the product contains no antimicrobial preservatives.1


1. Cyramza [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

Date of Last Review: August 07, 2020

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