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Cyramza ® (ramucirumab)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information:
Cyramza Summary of Product Characteristics (SmPC)
Cyramza® (ramucirumab): Extravasation
If extravasation occurs or is suspected, follow your local procedures for managing nonvesicant extravasation.
is a nonvesicant as it is an antibody in a neutral formulation that
is a specific receptor antagonist. No dedicated extravasation studies
were conducted in animals. However, local tolerance was investigated
in 2 repeat-dose toxicity evaluations in cynomolgus monkeys by
clinical observations and as part of the histopathological
evaluations. Intravenous administration of ramucirumab was well
tolerated at all dose levels. Mild, local injection-site reactions
were observed and consisted of mononuclear and/or polymorphonuclear
cells in the perivascular areas.1
extravasation occurs or is suspected, follow your local procedures
for managing nonvesicant extravasation.
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review:August 07, 2019
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