Cyramza ® (ramucirumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: www.medicines.org.uk (England, Scotland, Wales) or www.emcmedicines.com/en-GB/northernireland/ (Northern Ireland).

Cyramza® (ramucirumab): Density, pH and other physical and chemical properties

The density of Cyramza is 1.006 g/mL at 20°C (68°F). Further relevant physical and chemical characteristics are listed below.

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UK_cFAQ_RAM5021_DENSITY_PH_AND_OTHER_PHYSICAL_AND_CHEMICAL_PROPERTIES
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Physical and chemical characteristics of Cyramza

Appearance:  Clear to slightly opalescent and colorless to slightly yellow liquid without visible particles.1

Density:  1.006 g/mL at 20°C (68°F).1

Odor:  CYRAMZA does not have any characteristic or distinctive odour.1

Osmolality / Tonicity:  285 mmol/kg  (Range 250-320 mmol/kg).1

pH: 6  (Range: 5.7-6.3).1

pI  (Isoelectric Point):  The isoelectric point of ramucirumab is 8.6 to 9.4.1

Photostability: Like other proteins, the ramucirumab drug product is expected to undergo modifications under extreme light exposure conditions.  Exposure to ambient light during dose preparation and administration does not adversely affect the drug product.1

Specific Gravity: 1.006  (no units).1

Viscosity:  1.02cp at room temperature (25°C).1

References

1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 21 March 2022


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