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Cyramza Summary of Product Characteristics (SmPC)
Cyramza® (ramucirumab): Administration Using Filter
Administer ramucirumab via infusion pump. A separate infusion line must be used for the infusion and the line must be flushed with sterile sodium chloride (0.9%) solution for injection at the end of the infusion.
Using a Protein-Sparing Filter
filter is recommended to remove any possible particles (which include
micro-organisms) that may have been inadvertently introduced during
the preparation for infusion. Ramucirumab is compatible with a 0.2
micron protein sparing (low protein binding) filter and a 0.2
micron protein sparing (low protein binding) filter of at least 4.2
area may be used for administration.1
of the Same Filter
clinical studies, when ramucirumab was administered in combination
with another treatment, the filter was changed between the
administration of ramucirumab and the administration of other
refer to the local labeling for other products for details on
Using the Same Infusion Line
is acceptable to use a single/same IV line to administer ramucirumab
either before, or after, another medication if the infusion line used
is properly flushed with normal saline prior to administering the
ramucirumab through the same line.1
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review:April 17, 2020
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