Cyramza ® (ramucirumab)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: (England, Scotland, Wales) or (Northern Ireland).

Cyramza® (ramucirumab): Administration - Information on filter and infusion line usage

Administer via infusion pump. A separate infusion line with a protein-sparing 0.22-micron filter must be used for the infusion and the line must be flushed with sodium chloride 9 mg/ml (0.9%) solution for injection at the end of the infusion.


Administration using a protein-sparing filter

The filter is recommended to remove any possible particles (which include micro-organisms) that may have been inadvertently introduced during the preparation for infusion.

Ramucirumab is compatible with a 0.2 micron protein sparing (low protein binding) filter of at least 4.2 cm2 surface area.1

Can the same filter be used when Cyramza is administered with another treatment?

In clinical studies, when ramucirumab was administered in combination with another treatment, the filter was changed between the administration of ramucirumab and the administration of other products.1 Please refer to the local labeling for other products for details on administration.

Administration using the same infusion line

It is acceptable to use a single/same intravenous (IV) line to administer ramucirumab either before, or after, another medication if the infusion line used is properly flushed with normal saline prior to administering the ramucirumab through the same line.1


1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 24 March 2022

Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request