and Prepare Ramucirumab for Administration
the infusion solution using aseptic technique to ensure the sterility
of the prepared solution.1
vial of ramucirumab is intended for single use only.1
Inspect the contents of the vials for particulate matter and
discoloration prior to dilution. If particulate matter or
discolorations are identified, discard the vial
Calculate the dose and the required volume of ramucirumab needed to
prepare the infusion solution.
Dilute ramucirumab as required to achieve a final volume of 250 mL.
Only use sterile sodium chloride (0.9%) solution for injection as a
case of prefilled IV infusion container usage: based on the
calculated volume of ramucirumab, remove the corresponding volume of
sterile sodium chloride (0.9%) solution for injection from the
prefilled 250-mL IV container. Aseptically transfer the calculated
volume of ramucirumab to the IV container. The final total volume in
the container should be 250 mL.
case of empty IV infusion container usage: aseptically transfer the
calculated volume of ramucirumab into an empty IV container. Add a
sufficient quantity of sterile sodium chloride (0.9%) solution for
injection to the container to make the total volume 250 mL.
The container should be gently inverted to ensure adequate mixing.
not freeze or shake the infusion solution.
not dilute with other solutions or co-infuse with other electrolytes
Parenteral drug products should be inspected visually for particulate
matter prior to administration. If particulate matter is identified,
discard the infusion solution.
Discard any unused portion of ramucirumab left in a vial, as the
product contains no preservatives.1,2
ramucirumab as an IV infusion only. Do not administer ramucirumab as
an IV push or bolus.1
diluted ramucirumab infusion via infusion pump. A separate infusion
line with a protein sparing 0.22 micron filter must be used for the
infusion and the line must be flushed with sterile sodium chloride
(0.9%) solution for injection at the end of the infusion.1
Cyramza [summary of product characteristics]. Eli Lilly Nederland
B.V., The Netherlands.
Data on file, Eli Lilly and Company and/or one of its subsidiaries.