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Cymbalta Summary of Product Characteristics (SmPC)
Cases of overdose with duloxetine have been reported, alone or in combination with other medicinal products.
Cases
of overdoses, alone or in combination with other medicinal products,
with duloxetine doses of 5400 mg were reported. Some fatalities have
occurred, primarily with mixed overdoses, but also with duloxetine
alone at a dose of approximately 1000 mg. Signs and symptoms of
overdose (duloxetine alone or in combination with other medicinal
products) included somnolence, coma, serotonin syndrome, seizures,
vomiting and tachycardia.
No
specific antidote is known for duloxetine but if serotonin syndrome
ensues, specific treatment (such as with cyproheptadine and/or
temperature control) may be considered. A free airway should be
established. Monitoring of cardiac and vital signs is recommended,
along with appropriate symptomatic and supportive measures. Gastric
lavage may be indicated if performed soon after ingestion or in
symptomatic patients. Activated charcoal may be useful in limiting
absorption.
Duloxetine
has a large volume of distribution and forced diuresis,
haemoperfusion, and exchange perfusion are unlikely to be beneficial.
REFERENCE
Cymbalta
[Summary of Product Characteristics]. Utrecht, The Netherlands: Eli
Lilly Nederland B.V.
Date of Last Review:December 07, 2018
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