Trulicity ® (dulaglutide)

Can Trulicity® (dulaglutide) be used in patients with impaired hepatic function?

Use Trulicity with caution in patients with impaired hepatic function. No dose adjustment is needed based on hepatic impairment.


Clinical Pharmacology Study: Impaired Hepatic Function

A phase 1, single dose, clinical pharmacology study in patients with varying hepatic impairment showed no relevant changes in the pharmacokinetics of dulaglutide.1

Compared with participants with normal hepatic function, dulaglutide systemic exposure decreased by

  • 23% in patients with mild hepatic impairment
  • 33% in patients with moderate hepatic impairment, and
  • 21% in patients with severe hepatic impairment.1

The maximum serum concentration (Cmax) was decreased by a similar magnitude.1


1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: July 30, 2021

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