Trulicity ® (dulaglutide)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Trulicity Summary of Product Characteristics (SmPC)

Can Trulicity® (dulaglutide) be used in patients with impaired hepatic function?

Use Trulicity with caution in patients with impaired hepatic function. No dose adjustment is needed based on hepatic impairment.

UK_cFAQ_GLP047_IMPAIRED_HEPATIC_FUNCTION
UK_cFAQ_GLP047_IMPAIRED_HEPATIC_FUNCTION
en-GB

Clinical Pharmacology Study: Impaired Hepatic Function

A phase 1, single dose, clinical pharmacology study in patients with varying hepatic impairment showed no relevant changes in the pharmacokinetics of dulaglutide.1

Compared with participants with normal hepatic function, dulaglutide systemic exposure decreased by

  • 23% in patients with mild hepatic impairment
  • 33% in patients with moderate hepatic impairment, and
  • 21% in patients with severe hepatic impairment.1

The maximum serum concentration (Cmax) was decreased by a similar magnitude.1

References

1Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: July 30, 2021


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